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Nitazoxanide
Uses:
Nitazoxanide is used to treat diarrhea in children and adults caused by the protozoa Cryptosporidium or Giardia. Protozoa are suspected as the cause when diarrhea lasts more than 7 days. Nitazoxanide is in a class of medications called antiprotozoal agents.
Identifiers
- CAS No:
- [55981-09-4]
- BRN No:
- -
- UN No:
- -
Properties
- Molecular Formula:
- C12H9N3O5S
- Molecular Weight:
- 307.28 g/mol
Specifications
| Sr. No. | Test | Limits |
|---|---|---|
| 1 | Description | Light Yellow powder |
| 2 | Solubility | Freely soluble in Dimethylformamide, slightly soluble in chloroform and sparingly soluble in acetone. |
| 3 | Identification By | |
| a. By FTIR | IR spectra of the sample should be concordant to that of the Nitazoxanide standard | |
| b. Identification By HPLC | In the Test for Assay, the retention time of the major peak as obtained in chromatogram of sample should be corresponds to that obtained in chromatogram of Standard | |
| 4 | Loss on Drying (%, w/w) | Not more than 0.5 |
| 5 | Residue on Ignition (%, w/w) | Not more than 0.1 |
| 6 | Melting Point (°C) | Between 199°C to 205°C |
| 7 | Heavy Metals (ppm) | Not more than 10 |
| 8 | Related Substances by HPLC (%) | |
| Impurity A | Not more than 1.0 | |
| Any individual impurity | Not more than 0.5 | |
| Total impurities | Not more than 1.5 | |
| 9 | Assay by HPLC (%, w/w) (As “C12H9N3O5S”, on dried basis) | Not more than 1.5 |
