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Brimonidine Tartrate

Uses: This medication is used to treat open-angle glaucoma or high fluid pressure in the eye. Lowering high fluid pressure in the eye reduces the risk of vision loss, nerve damage, or blindness. This medication lowers pressure by allowing better fluid drainage from within the eye and also by reducing the amount of fluid formed in the eye. It is known as an alpha agonist.
UN No:
Molecular Formula:
Molecular Weight:
442.22 g/mol


Sr. No. Test Limits
1 Description White or slightly yellowish or slightly
brownish powder
2 Solubility Soluble in Water, Practically insoluble in
anhydrous Ethanol and in Toluene
3 Identification
a. Specific Optical Rotation Should comply the test
b. By FTIR The infrared absorption Spectrum of
the sample should be concordant with
that of Standard
4 Loss on Drying (%, w/w)
(At 105°C for 3 hrs)
Not more than 0.5
5 Sulphated Ash (%, w/w) Not more than 0.2
6 Specific Optical Rotation (°)
[C=1% w/v, in Water at 25°C, On
dried substance]
Between +9.00 to +10.5
7 Related Substances by HPLC (%, w/w)
Unspecified impurities
Total impurities
Not more than 0.10
Not more than 0.2 (Disregard limit: 0.05%)
8 Assay by Potentiometry (%,w/w)
,On dried substance)
Not more than 0.2